Description
The catalytic subunit C-alpha of PKA (PKAca) is a member of the Ser/Thr protein kinase family and has been assigned to chromosome region 19p13.1. Null mutation in PKAca leads to early postnatal lethality in the majority of C-alpha knockout mice. Surprisingly, a small percentage of C-alpha knockout mice, although runted, survived to adulthood. In these animals, compensatory increases in C-beta levels occurred in brain whereas many tissues, including skeletal muscle, heart, and sperm, contained less than 10% of the normal PKA activity